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目的探讨乳杆菌活菌胶囊联合甲硝唑栓治疗细菌性阴道病的疗效及预防复发作用。方法将88例细菌性阴道病患者的随机分为观察组和对照组。观察组患者予以乳杆菌活菌胶囊和甲硝唑栓联合治疗,对照组患者予以单纯的甲硝唑栓治疗。乳杆菌活菌胶囊阴道放置,每次1粒,每晚1次,连用10 d。甲硝唑栓阴道放置,阴道放置,每次1粒,每晚1次,连用10 d。两组患者治疗期间及复查前禁止性生活,避免冲洗阴道及使用抗生素和微生态制剂。观察两组患者治疗停药后2周的临床疗效,并比较随访3个月及6个月内的复发率。结果治疗停药后2周,观察组的临床总有效率为95.45%,明显高于对照组的81.82%(χ2=4.06,P<0.05)。治疗后进行随访,观察组的3个月及6个月内复发率分别为7.14%和16.67%,均明显低于对照组的25.00%和38.89%(χ2=4.75和4.87,P<0.05)。结论乳杆菌活菌胶囊联合甲硝唑栓治疗细菌性阴道病具有较好的疗效,并降低其复发率,具有治疗与预防细菌性阴道病的双重作用。
Objective To investigate the efficacy of Lactobacillus live capsule and metronidazole suppository in the treatment of bacterial vaginosis and to prevent the recurrence. Methods 88 patients with bacterial vaginosis were randomly divided into observation group and control group. Patients in the observation group were treated with Lactobacillus live capsule and metronidazole suppository, and patients in the control group were treated with metronidazole suppository alone. Lactobacillus live vaginal capsules placed, each one, night 1, once every 10 d. Metronidazole suppository placed vagina, vaginal, each 1, night 1, once every 10 d. Two groups of patients during treatment and review before the prohibition of sexual life, to avoid washing the vagina and the use of antibiotics and probiotics. The clinical efficacy of two weeks after treatment was observed in two groups of patients and the recurrence rates were compared between the two groups at 3 months and 6 months follow-up. Results After 2 weeks of treatment, the total effective rate in the observation group was 95.45%, significantly higher than 81.82% in the control group (χ2 = 4.06, P <0.05). After treatment, the recurrence rates in the observation group were 7.14% and 16.67% within 3 months and 6 months, respectively, which were significantly lower than those in the control group (25.00% vs 38.89%, χ2 = 4.75 and 4.87, P <0.05). Conclusion Lactobacillus live capsule combined with metronidazole suppository has a good curative effect in treating bacterial vaginosis and reducing its recurrence rate, which has the dual effect of treating and preventing bacterial vaginosis.