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目的 :探讨内皮素 (ET)在慢性肾小球肾炎发病中所起的作用。方法 :检测正常人、40例慢性肾炎患者肾组织局部ET - 1、血浆ET - 1和 2 4h尿ET - 1排泄量 ,以及血肌酐 (Scr)、尿素氮 (Bun) ,2 4h尿蛋白定量 (Pro)和内生肌酐清除率 (Ccr)。结果 :40例慢性肾小球肾炎患者肾组织局部、血、尿ET - 1均较正常对照组明显升高 (P <0 .0 1) ,且血、尿ET - 1与Bun、Scr、Pro明显呈正相关 ,与Ccr呈负相关。结论 :内皮素可能参与慢性肾小球肾炎发病及疾病进展 ,血尿ET - 1可作为判断肾炎活动性的一个临床指标
Objective: To investigate the role of endothelin (ET) in the pathogenesis of chronic glomerulonephritis. Methods: The levels of ET - 1, ET - 1 and 24 hours urinary ET - 1 excretion and the levels of serum creatinine (Scr), blood urea nitrogen (Bun) and 24 hours urinary protein in 40 patients with chronic nephritis were measured. (Pro) and endogenous creatinine clearance (Ccr). Results: The serum, urinary levels of ET - 1 in 40 patients with chronic glomerulonephritis were significantly higher than those in normal controls (P <0.01) Obviously positive correlation and negative correlation with Ccr. Conclusion: Endothelin may be involved in the pathogenesis and progression of chronic glomerulonephritis. ET - 1 in hematuria may be used as a clinical indicator to judge the activity of nephritis