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目的证实消化性溃疡与阻塞性黄疸的相关性。方法经内镜证实的溃疡患者289例,从无溃疡患者中随机挑选290例设为对照组,进行去除混杂因素的非条件的 logistic 回归分析。比较消化性溃疡各病种之间与阻塞性黄疸发生率的差异,消化性溃疡中的高位梗阻与低位梗阻发生率的差异,溃疡组与无溃疡组的肝功能各项指标的对比,黄疸的发生时间与消化性溃疡发生的关系,以及胃溃疡与十二指肠溃疡发生率的差异。结果溃疡组的阻塞性黄疸发病率及黄疸指数明显高于对照组(P<0.01),低位梗阻与高位梗阻对比,低位梗阻患者的消化性溃疡发生率高(P<0.01),十二指肠与胃溃疡发生率两组有显著差别,各病种间的溃疡发生率有明显差别,溃疡的发生率与黄疸持续的时间相关。结论本研究进一步证实了消化性溃疡与阻塞性黄疸有明显的相关性,梗阻性黄疸导致高胃酸在十二指肠溃疡形成中的重要作用。
Objective To confirm the correlation between peptic ulcer and obstructive jaundice. Methods A total of 289 ulcer patients confirmed by endoscopy were randomly selected from non-ulcer patients as control group, and unconditional logistic regression analysis was performed to remove confounding factors. Comparing the difference between the incidence of obstructive jaundice and the incidence of obstructive jaundice among the different types of peptic ulcer, the difference between the high obstruction and the low obstruction in the peptic ulcer, the comparison of various indexes of liver function between the ulcer group and the non-ulcer group, Occurs with the occurrence of peptic ulcer and gastric ulcer and duodenal ulcer incidence differences. Results The incidence of obstructive jaundice and jaundice index in ulcer group were significantly higher than those in control group (P <0.01). The incidence of peptic ulcer was higher in patients with low obstruction than in low obstruction group (P <0.01) There was a significant difference between the two groups in the incidence of gastric ulcer and the incidence of ulcer among the various diseases. The incidence of ulcer was related to the duration of jaundice. Conclusions This study further confirms that there is a clear correlation between peptic ulcer and obstructive jaundice, and that obstructive jaundice causes an important role of high gastric acid in the formation of duodenal ulcer.