目的探讨血浆神经肽Ｙ（ＮＰＹ）在高血压、脑梗塞发病中的作用。方法测定４８例高血压、５７例脑梗塞患者的血浆ＮＰＹ并与正常对照组比较。结果正常组ＮＰＹ含量为（９００８±３２９８）ｎｇ·Ｌ－１，高血压组ＮＰＹ含量为（１２２０７±３０２９）ｎｇ·Ｌ－１，脑梗塞组ＮＰＹ含量为（１５１３９±４９３６）ｎｇ·Ｌ－１。与正常组比较，高血压组和脑梗塞组血浆的ＮＰＹ显著高于对照组（Ｐ＜００５），且随着年龄的增加而升高。结论ＮＰＹ异常升高参与了高血压和脑梗塞的发病，同时，ＮＰＹ的含量变化不仅与病理因素有关，也受机体老化因素的影响。 Objective To investigate the role of plasma neuropeptide Y (NPY) in the pathogenesis of hypertension and cerebral infarction. Methods Plasma NPY in 48 patients with hypertension and 57 patients with cerebral infarction was measured and compared with the normal control group. Results The NPY content in the normal group was (9008 ± 3298) ng · L-1, the NPY content in the hypertension group was (1220 ± 3029) ng · L-1, the NPY content in the cerebral infarction group was (151  39 ± 4936) ng · L-1. Compared with the normal group, plasma NPY in hypertensive group and cerebral infarction group was significantly higher than that in the control group (P <005), and increased with age. Conclusions The abnormal increase of NPY is involved in the pathogenesis of hypertension and cerebral infarction. At the same time, the change of NPY content is not only related to the pathological factors but also affected by the aging factors of the body.