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采用放射免疫法测定４５例急性脑梗塞患者血清肿瘤坏死因子（ＴＮＦ）含量，并与３０例脑动脉硬化患者及２７例健康体检者进行比较。结果表明脑梗塞患者ＴＮＦ水平明显增高，脑梗塞组ＴＮＦ为７．１９±１．６７ｎｇ／ｍｌ，脑动脉硬化组为２．３０±１．０６ｎｇ／ｍｌ，正常对照组为１．４１±０．２３ｎｇ／ｍｌ。脑梗塞组与脑动脉硬化组比较有显著性差异（Ｐ＜０．００１）；与正常对照组比较有极显著性差异（Ｐ＜０．００１）。重型脑梗塞患者血清ＴＮＦ含量亦较轻型患者显著增高。重型ＴＮＦ含量为１１．３２±１．４３ｎｇ／ｍｌ，轻型为６．９０±１．５０ｎｇ／ｍｌ（Ｐ＜０．０５）。提示ＴＮＦ参与脑梗塞的发生、发展全过程，脑梗塞患者血清ＴＮＦ含量测定可作为判断患者病情、治疗及预后的一项免疫学指标。
Serum tumor necrosis factor (TNF) levels were measured by radioimmunoassay in 45 patients with acute cerebral infarction and compared with 30 patients with cerebral arteriosclerosis and 27 healthy subjects. The results showed that the levels of TNF in patients with cerebral infarction were significantly increased. The levels of TNF in cerebral infarction group were 7.19 ± 1.67ng / ml, those in cerebral arteriosclerosis group were 2.30 ± 1.06ng / ml and those in normal control group were 1.41 ± 0. 23ng / ml. There was significant difference between cerebral infarction group and cerebral arteriosclerosis group (P <0.001). Compared with normal control group, there was significant difference (P <0.001). Serum TNF levels in patients with severe cerebral infarction were also significantly higher than in patients with mild type. The level of heavy TNF was 11.32 ± 1.43 ng / ml and light was 6.90 ± 1.50 ng / ml (P <0.05). Suggesting that TNF involved in the occurrence of cerebral infarction, the whole process of development, determination of serum TNF levels in patients with cerebral infarction can be used as an immunological indicators to determine the patient’s condition, treatment and prognosis.