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随着肿瘤免疫研究的深入,人们对NK细胞的抗肿瘤效应有了新的认识,NK细胞的基础和临床应用研究已成为近年来研究的热点。如何纯化及体外大量扩增建立可连续传代培养的NK细胞系,开展对NK细胞的基础和临床抗肿瘤研究有其重要意义。以下对NK细胞建系状况及临床应用研究进展作一综述。
With the deepening of tumor immunity research, people have a new understanding of the antitumor effect of NK cells. The study of basic and clinical application of NK cells has become a hot spot in recent years. How to purify and in vitro expansion of a large number of NK cell lines can be continuously subcultured to carry out the basic and clinical anti-tumor NK cell has its significance. The following is a review of the research progress of NK cell lineage and clinical application.