论文部分内容阅读
给实验动物慢性摄入乙醇平均每只每天量为８．０ｇ／ｋｇ体重，历时９０天。结果显示：（１）大鼠肝细胞浆中醇脱氢酶（ＡＤＨ）和谷胱甘肽硫转移酶（ＧＳＴ）活性，染毒组较对照组均明显减低（Ｐ＜０．０１）；（２）大鼠肝细胞浆内谷胱甘肽（ＧＳＨ）含量染毒组较对照组也明显减低（Ｐ＜０．０１）。提示ＡＤＨ和ＧＳＴ活性及ＧＳＨ含量在酒精性肝病发病中起着重要作用。
Chronic intake of ethanol into experimental animals averaged 8.0 g / kg body weight per day for 90 days. The results showed that: (1) The activity of alcohol dehydrogenase (ADH) and glutathione S - transferase (GST) in hepatic cytoplasm of rats were significantly decreased compared with the control group (P <0.01); ( 2) The content of glutathione (GSH) in the hepatic cytoplasm of rats was significantly lower than that of the control group (P <0.01). It is suggested that ADH and GST activity and GSH content play an important role in the pathogenesis of alcoholic liver disease.