高血糖是糖尿病(diabetes mellitus,DM)最具特征性的临床表现,它可以增加活性氧(reactive oxygen species,ROS)的产生,引发氧化应激(oxidative stress,OS),从而导致DM时细胞生理功能失调。OS是指机体遭受各种有害刺激时,体内高活性分子如ROS和活性氮(RNS)产生过多,氧化程度超出氧化物的清除,氧化系统和抗氧化系统失衡,进[1] Hyperglycemia is one of the most characteristic clinical manifestations of diabetes mellitus (DM). It can increase the production of reactive oxygen species (ROS), trigger oxidative stress (OS) and lead to the change of cell physiology Dysfunction OS refers to the body subjected to a variety of harmful stimuli, the body of high activity molecules such as ROS and reactive nitrogen (RNS) produce too much, the oxidation of excess oxide removal, oxidation system and antioxidant system imbalance, into [1]