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目的 :揭示整合素αvβ6和MMP-9与胃癌病理生物学特征的关系。方法 :以141例胃癌患者的病变组织和周围组织标本为研究对象,运用En Vision免疫组化方法,分析以上患者的病变组织中整合素αvβ6和MMP-9的表达与胃癌病理生物学特征间的关系。结果 :整合素αvβ6和MMP-9在胃癌组织中的表达的共同点在于,它们都受到组织分化程度、Lauren分型、淋巴结转移与否(N分期)和TNM分期等因素的影响关(P<0.01),区别在于MMP-9还与浸润深度相关(P<0.01)。结论 :胃癌的浸润、转移是影响整合素αvβ6和MMP-9的高表达的重要因素,可参考二者的表达,来评估和指导确定胃癌患者治疗的用药目标和提供预后的参考指标。
Objective: To reveal the relationship between integrin αvβ6 and MMP-9 and pathological biological characteristics of gastric cancer. METHODS: The lesions and surrounding tissues of 141 patients with gastric cancer were studied. EnVision immunohistochemistry was used to analyze the expression of integrin αvβ6 and MMP-9 in pathological tissues of the above patients. relationship. RESULTS: The common features of integrin αvβ6 and MMP-9 expression in gastric cancer tissues were that they were affected by factors such as histological grade, Lauren’s type, lymph node metastasis (N stage), and TNM staging (P< 0.01), the difference being that MMP-9 was also associated with depth of invasion (P<0.01). Conclusion : Invasion and metastasis of gastric cancer are important factors affecting the high expression of integrin αvβ6 and MMP-9. The expression of integrin αvβ6 and MMP-9 can be used as references to assess and guide the use of drugs to treat patients with gastric cancer and provide reference indicators for prognosis.