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美《最新处方》第5卷第7期(1979年7月)第75页报道:美国临床药理和治疗学会(ASCPT)对于不良反应的新近报告颇为关切。已提出的问题是:在某些易感的个体中,心得安能否引起糖尿病。另外,也报道了二种新药物的相互作用,其中之一可能是致命性的,即:安侬痛和安定合用,静脉注射,可引起呼吸抑制;安体舒通使洋地黄毒甙的排除显著延缓。葡萄糖不耐受和心得安长期口服心得安引起的β-肾上腺能慢性阻断,可能使易感的人发生糖尿病——此或由于减弱胰岛素对葡萄糖的正常反应,抑或阻碍胰岛素的外周作
Volume 5, Issue 7, July 1979 (July 1979) Page 75 Report: The American Society of Clinical Pharmacology and Therapeutics (ASCPT) is concerned with recent reports of adverse effects. The question that has been raised is: In certain susceptible individuals, empathy can cause diabetes. In addition, the interaction of two new drugs has also been reported, one of which may be fatal, namely: Anong Tong and diazepam, intravenous injection can cause respiratory depression; spironolactone digoxin digoxin Significant delay. Glucose Intolerance and Irritability Long-term oral propranolol causes chronic blockade of the beta-adrenal glands, which may lead to diabetes in susceptible individuals - either because of the diminished insulin’s normal response to glucose or obstructing the periphery of insulin