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目的：研究对颅脑术后患者采用丙泊酚预防躁动的临床效果及护理要点。方法选取本院于2014年9月~2015年9月收治的78例重型颅脑损伤术后患者，均采用丙泊酚治疗，观察其镇静效果并总结护理要点。结果患者在经丙泊酚治疗后4~8 h内镇静效果最好，患者使用丙泊酚前，生命体征情况与使用后无明显差异，>0.05。结论颅脑损伤患者躁动期应用丙泊酚后镇静效果好，对呼吸功能影响较小，同时护理过程中做好生命体征监测，判断患者镇静程度及对患者做好安全保护，对于预防颅脑术后患者出现躁动有积极意义。“,”Objective To study the use of propofol in patients with craniocerebral surgery to prevent clinical effect and nursing points of agitation. Methods Select 78 cases in our hospital from 2014.9 to 2015.9 admitted during the period of postoperative patients with severe head injury,adopt propofol treatment,observe its calming effects and summarize nursing key points.Results After treatment with propofol in patients with 4 to 8 h sedative effect is best,the patient using propofol,vital signs and no obvious difference after using, ﹥0.05.Conclusion Craniocerebral injury patients with agitation period after application of propofol sedation effect is good,small impact on the respiratory function,at the same time nursing process for monitoring vital signs,to determine degree of calm and keep safety of patients,patients with for prevention of postoperative patients with craniocerebral appear restless has positive significance.