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利用光气法分别以L-谷氨酸和L-丙氨酸为原料,合成了γ-谷氨酸苄酯-NCA单体和L-丙氨酸-NCA单体,再以三乙胺为引发剂,合成了聚(L-丙氨酸)-聚(γ-谷氨酸苄酯)(PLA50-b-PBLG20)双嵌段共聚多肽,并用乙醇胺对其中的PBLG嵌段进行亲核取代,把疏水性的苄酯侧链变为亲水性的羟烷酰胺侧链,得到双亲性的聚(L-丙氨酸)-聚羟乙基谷氨酰胺(PLA-b-PHEGA)双嵌段共聚多肽.利用红外光谱和核磁共振谱对产物进行了表征,用TEM研究了双嵌段共聚多肽PLA50-b-PHEGA20在水溶液中的自组装.研究结果表明,双嵌段共聚多肽在水溶液中可自组装形成囊泡.
By the method of phosgene, L-glutamic acid and L-alanine were used as raw materials to synthesize the γ-glutamic acid benzyl ester-NCA monomer and L-alanine-NCA monomer, respectively, The poly (L-alanine) -poly (γ-glutamic acid benzyl ester) (PLA50-b-PBLG20) diblock copolymer was synthesized and its nucleophilic substitution was performed with ethanolamine. Hydrophilic benzyl ester side chains were changed to hydrophilic hydroxyalkanamide side chains to give amphipathic poly (L-alanine) -polyhydroxyethyl glutamine (PLA-b-PHEGA) diblock The copolymer was characterized by FT-IR and 1H-NMR and the TEM was used to study the self-assembly of diblock copolymer PLA50-b-PHEGA20 in aqueous solution.The results showed that the diblock copolymer could be synthesized in aqueous solution Self-assembly to form vesicles.