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目的探讨米非司酮与依沙吖啶联合用于终止中期妊娠引产的临床效果。方法回顾分析2008年1月至2012年12年孕16～27周要求终止妊娠的孕妇,随机分为观察组62例,对照组58例。观察组口服米非司酮,同时经腹向羊膜腔内注射依沙吖啶;对照组经腹向羊膜腔内注射依沙吖啶,不加用米非司酮。观察两组宫缩发动时间、总产程时间、阴道流血量、引产效果及软产道损伤情况。结果两组引产成功率100%,观察组在宫缩发动时间、总产程时间比对照组缩短,产后24h阴道流血量和软产道损伤率比对照组少,差异均有统计学意义(P<0.05)。结论米非司酮与依沙吖啶联合终止中期妊娠缩短了引产时间,减少产后出血,避免了软产道损伤,减轻患者痛苦,值得临床推广应用。
Objective To investigate the clinical efficacy of mifepristone combined with ethacridine in terminating labor induction in mid-term pregnancy. Methods A total of 62 pregnant women who required termination of pregnancy within 12 weeks of pregnancy from January 2008 to December 2012 were randomly divided into observation group (n = 62) and control group (n = 58). In the observation group, mifepristone was given orally, meanwhile, ethacridine was injected intraperitoneally to the amniotic cavity. In the control group, ethacridine was injected into the amniotic cavity without any mifepristone. Observe the two groups contractions time, total labor time, vaginal bleeding, induction of labor and soft birth canal injury. Results The success rate of induction of labor in both groups was 100%. The observation group had shorter duration of contractions and longer duration of labor than those in control group. The vaginal bleeding volume and the rate of soft birth canal injury after birth were less than those in control group (P <0.05) ). Conclusion Mifepristone combined with ethacridine termination of the second trimester of pregnancy shorten the induction of labor, reduce postpartum hemorrhage, to avoid soft birth canal injury, reduce patient suffering, worthy of clinical application.