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肌萎缩侧索硬化症是一种神经系统变性病,目前,在早期诊断该病、监测患者的病情变化及评估药物的疗效等方面虽尚缺乏明确特异性的生物学标记,但近年来,与之相关的生物学标记的研究在国内外还是取得了长足进步,本文综述患者脑脊液和血液中与肌萎缩侧索硬化症的诊断、临床表现及病情进展相关的生物学标记的研究进展,供同道们参考。
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. At present, there is a lack of specific and specific biomarkers in the early diagnosis of the disease, monitoring the patient’s condition and assessing the efficacy of the drug. However, in recent years, Related biological markers at home and abroad have made considerable progress, this review of patients with cerebrospinal fluid and blood and amyotrophic lateral sclerosis diagnosis, clinical manifestations and progression of biological markers related to the progress of research, for fellow For reference.