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肿瘤坏死因子 (ＴＮＦ)在肿瘤生物治疗中占有一定的地位 ,但原型肿瘤坏死因子毒副作用较明显 ,临床使用受到限制。为减轻毒副作用和提高疗效 ,上海第二军医大学神经生物学教研室应用生物工程技术改造制成了新型肿瘤坏死因子 (ｒｈＴＮＦ ＮＣ) ,为国家Ⅰ类新药。我科于 2 0 0 0
Tumor necrosis factor (TNF) occupies a certain position in tumor biological treatment, but the toxic and side effects of prototype tumor necrosis factor are obvious, and the clinical use is limited. In order to reduce the toxic and side effects and improve the curative effect, a new type of tumor necrosis factor (rhTNF NC) was made by Department of Neurobiology, Shanghai Second Military Medical University. My department was at 2000