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相对于良性肿瘤患者而言,恶性肿瘤患者组织中金属元素的浓度是增高还是降低仍不够清楚。尽管恶性肿瘤患者血清和组织中的锌和铜的浓度已被广泛研究,但其在致癌方面的准确作用尚不够清楚。与血清和血浆标本相比较,组织标本中必需元素和毒性元素浓度的研究很少。微波热能消化组织标本后,用原子吸收光谱法测定良恶性子宫和卵巢组织中镉、铜、锌、铁、镁、钙和镍的浓度。应用石英缝管原子捕集器提高火焰原子吸收法测定镉和铜的灵敏度。研究结果显示,恶性子宫肿瘤组织中铁的浓度明显高于良性肿瘤组织标本。相反,锌的浓度明显低于良性组织标本。其他微量元素的研究结果没有显著性差异。恶性卵巢肿瘤组织标本中铜和钙的浓度高于良性组织标本。良恶性卵巢组织中镁、铁、锌的浓度差异不具有统计学意义。
It is not clear whether the concentration of metal elements in the tissue of patients with malignant tumors is higher or lower than in patients with benign tumors. Although the concentrations of zinc and copper in the serum and tissues of patients with malignant tumors have been extensively studied, its exact role in carcinogenesis is poorly understood. In contrast to serum and plasma samples, there is little research into the concentration of essential and toxic elements in tissue samples. After digestion of tissue samples by microwave thermal energy, concentrations of cadmium, copper, zinc, iron, magnesium, calcium and nickel in benign and malignant uterine and ovarian tissues were determined by atomic absorption spectrometry. Application of quartz tube atomic trap enhances the sensitivity of flame atomic absorption spectrometry in the determination of cadmium and copper. The results showed that the concentration of iron in malignant uterine tumor tissue was significantly higher than that of benign tumor tissue specimens. In contrast, the zinc concentration was significantly lower than that of benign tissue specimens. The results of other trace elements did not differ significantly. Malignant ovarian tumor tissue samples of copper and calcium concentrations higher than the benign tissue specimens. The difference of the concentrations of magnesium, iron and zinc in benign and malignant ovarian tissues was not statistically significant.