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目的 :为加速本市结核病控制进程。方法 :按照结核病诊断细菌学检验规程的要求 ,对本市 2 6例复、难治肺结核患者进行现场痰涂片、改良酸罗氏培养、 L型结核菌培养、菌型初步鉴定、药物敏感试验。结果 :分离出 11例结核耐药菌株 ,其中结核分支杆菌 10例 ,非典型分支杆菌 1例。同时耐 HR+1种药物以上患者 5例。 L型结核菌检出率 5 0 % (13/2 6 ) ,其中涂片 (- )常规培养 (- )的肺结核病人 L型结核检出 5例。结论 :采取医务人员直接督导化疗 (DOTS)是防止耐药产生关系 ,并建议在判定结核细菌学治愈的标准时 ,若 L型结核菌也为阴性 ,才是真正的细菌学治愈。
Purpose: To speed up the city’s tuberculosis control process. Methods: According to the requirement of bacteriological test of tuberculosis diagnosis, 26 patients with complicated and refractory pulmonary tuberculosis in our city were treated with on-the-spot sputum smear, modified acid Roche culture, culture of L-type tubercle bacillus, initial identification of bacteria and drug sensitivity test. Results: 11 cases of tuberculosis resistant strains were isolated, including 10 cases of Mycobacterium tuberculosis and 1 case of atypical mycobacterium. At the same time HR + 1 kinds of drugs in patients with more than 5 cases. The detection rate of L type tuberculosis was 50% (13/2 6), of which 5 cases were detected by L - type tuberculosis of smear (-) routine culture (-). CONCLUSIONS: Direct medical-to-chemotherapy (DOTS) by medical staff is a preventable drug-resistant relationship and suggests true bacteriological cure if L TB is also negative when determining the criteria for TB tuberculosis cure.