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目的:确定祛除白附子麻辣刺激性新技术方法的可行性。方法:采用研磨式超微粉碎法;以中位粒径达11.85μm,最大粒径64μm,90%的粒度在28μm以下为质量控制标准;采用小鼠急性毒性、兔眼结膜刺激、镇静等动物实验,比较了白附子生品、老工艺炮制品、新技术炮制品的药理作用。结果:白附子经超微粉碎后,其毒性、刺激性由强到弱为白附子生品>老工艺炮制品>新技术制品,药效作用与生品、老工艺制品基本一致。结论:白附子经超微粉碎后,可基本祛除白附子麻辣刺激性,同时保持其原有的药效。
Objective: To determine the feasibility of a new technique that eliminates spicy irritation of the white tuber. Methods: The method of grinding with ultrafine grinding; median particle size of 11.85μm, maximum particle size of 64μm, 90% particle size below 28μm are quality control standards; using mouse acute toxicity, rabbit eye conjunctiva stimulation, sedation and other animals The experiment compared the pharmacological effects of white aconite raw material, old artillery products, and new technology processed products. RESULTS: After superfine pulverization, the white monkshood was poisonous and irritant from strong to weak. It was aconite raw product> old craft processed product> new technology product, and the effect of pharmacodynamics was basically the same as that of raw product and old craft product. Conclusion: After superfine pulverization, white monkshood can basically remove the spicy irritation of white monkshood, while maintaining its original efficacy.