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目的探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)患者血管内皮祖细胞(endothelial progenitor cells,EPC)生物学变化的要点。方法选取2012年3月-2015年5月深圳市妇幼保健院收治的晚孕妊娠期ICP患者284例作为观察组,另取同一时间就诊的晚孕妊娠期正常患者284例作为对照组。分析两组患者的EPC生物学变化特征。结果观察组的血清胆汁酸含量相比于对照组显著提升,两组比较差异具有统计学意义(P<0.05);观察组的EPC水平、增殖百分比、迁移数量和粘附数量相比于对照组均显著下降,两组比较差异具有统计学意义(P<0.05)。结论 ICP孕妇体内胆汁酸水平同EPC水平有一定相关性,低EPC会影响体内胎儿胎盘血循环,需要临床医生予以足够重视。
Objective To investigate the biological changes of endothelial progenitor cells (EPC) in patients with intrahepatic cholestasis of pregnancy (ICP). Methods From March 2012 to May 2015, 284 pregnant women with pregnancy in pregnancy were enrolled as the observation group. Another 284 normal pregnant women with gestational age at the same time were selected as the control group. The biological characteristics of EPCs in two groups were analyzed. Results Compared with the control group, the serum bile acid level in the observation group increased significantly (P <0.05). Compared with the control group, the levels of EPCs, the percentage of proliferation, the number of migration and the number of adhesion in the observation group Were significantly decreased, the difference between the two groups was statistically significant (P <0.05). Conclusion The level of bile acid in ICP pregnant women is related to the level of EPC. Low EPC may affect the fetal blood circulation in the fetus and requires clinicians to pay enough attention to it.