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目的:探讨中药鱼腥草注射液与青霉素钠、氧氟沙星氯化钠注射液、头孢拉定注射液和阿昔洛韦、更昔洛韦和利巴韦林注射液的配伍稳定性。方法:观察鱼腥草注射液与6种药物分别配伍后的外观,pH和含量变化,用紫外分光光度法进行光谱扫描。结果:鱼腥草注射液与青霉素钠和更昔洛韦配伍后产生沉淀,与阿昔洛韦配伍后含量显著下降,与头孢拉定配伍后2h内性质稳定,24h内含量显著下降,与利巴韦林注射液和氧氟沙星氯化钠注射液配伍后外观,含量和pH均无明显变化,配伍后性质稳定。结论:鱼腥草注射液与氧氟沙星氯化钠注射液、利巴韦林注射液联合使用,呈阴性结果;与青霉素钠、阿昔洛韦、更昔洛韦不能混合使用,呈阳性结果;与头孢拉定配伍应在2h内滴完。
OBJECTIVE: To investigate the compatibility of Houttuynia Cordata injection with penicillin sodium, ofloxacin sodium chloride injection, cefradine injection and acyclovir, ganciclovir and ribavirin injection. Methods: The changes of the appearance, pH and content of Houttuynia Cordata injection after compatibility with six kinds of drugs were observed. The spectrum was scanned by UV spectrophotometry. Results: Houttuynia injection and penicillin sodium and ganciclovir compatibility after precipitation, and the compatibility of acyclovir significantly decreased content, and compatibility with cephradine within 2h after the stable, content was significantly decreased within 24h, and ribavir Lin injection and ofloxacin sodium chloride injection compatibility, appearance, content and pH no significant change after the compatibility of stable. Conclusion: Houttuynia injection and ofloxacin sodium chloride injection, ribavirin injection combined with negative results; and penicillin sodium, acyclovir, ganciclovir can not be mixed, was positive Results; with cephradine should be drip finished within 2h.