Objective:To search systematically the application situation of the outcomes in the randomized con-trolled trials (RCTs) of perimenopausal syndrome treated with acupuncture and moxibustion so as to pro-vide the foundation for the core outcome sets in treatment of periomenopausal syndrome with acupunc-ture and moxibustion.Methods:The articles of RTCs on perimenopausal syndrome treated with acupuncture and moxibustion were searched in China National knowledge Infrastructure (CNKI),Wanfang Data Knowledge Service Plat-form (Wanfang),VIP Chinese Journal Service Platform (VIP),Pubmed,Excerpt medica database (Embase)and Cochrane central register of controlled trials (CENTRAL) databases from January 1,2010 to December 31,2020.Two reviewers screened the articles,extracted data and analyzed the application of outcomes in the eligible trials independently.Results:A total of 9391 articles were retrieved initially and 79 articles of them were eligible,including 43 articles in English and 36 articles in Chinese.115 outcomes were involved totally and collected according to 7 outcome domains,of which,the effective rate was the outcome with the highest use frequency.35 articles reported adverse events and 17 articles reported the effect in followup.Conclusion:At present,the outcomes of RCTs on perimenopausal syndrome in treatment with acupunc-ture and moxibustion are big in divergence,absent in normalization and lack of indicators for long-term prognosis and economics outcomes,as well as have the issues on the incomplete reports on the differ-entiation between the primary and the secondary outcomes,safety indicators and followup outcomes.It needs to construct the core outcome sets in line with the characteristics of acupuncture-moxibustion discipline so as to improve the quality of clinical trials of acupuncture and moxibustion.