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目的探讨前列腺间质肉瘤(PSS)的临床病理特征。方法回顾性分析3例PSS患者临床资料,采用免疫组织化学标记,在显微镜下观察组织学形态及免疫组化表达。结果3例均行前列腺姑息性肿瘤切除术,光镜下前列腺间质肉瘤主要由排列成束状、编织状的长梭形细胞构成,细胞异型性明显。免疫组化肿瘤细胞波形蛋白(Vimentin)、CD34及PR呈阳性表达。随访1～5年,2例于术后2年内死于肿瘤广泛转移,另1例术后5年出现肝脏等处转移。结论PSS是临床少见的恶性肿瘤,预后差。CD34阳性是诊断该肿瘤的重要依据之一。根治性前列腺切除是最可靠的治疗方案,化疗、放疗及抗激素类药物有一定疗效。
Objective To investigate the clinicopathological features of prostate stromal sarcoma (PSS). Methods The clinical data of 3 patients with PSS were retrospectively analyzed. Immunohistochemical staining was used to observe the histological and immunohistochemical expression under microscope. Results All patients underwent palliative resection of the prostate gland. Under light microscopy, the stromal sarcoma mainly consisted of long, spindle-shaped cells arranged in a bundle or braid. The cell atypia was obvious. Immunohistochemical tumor cells Vimentin, CD34 and PR were positive expression. Followed up for 1 to 5 years, 2 cases died of extensive tumor metastasis within 2 years after operation, and the other 1 case showed liver metastasis 5 years after operation. Conclusion PSS is a rare clinical malignancy with poor prognosis. CD34 positive diagnosis of the tumor is one of the important basis. Radical prostatectomy is the most reliable treatment options, chemotherapy, radiotherapy and anti-hormone drugs have a certain effect.