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目的对不同质子泵抑制剂对消化性溃疡出血的疗效及疗效-费用分析进行分析。方法83例消化性溃疡出血病人随机分为4组,分别给予:①静脉注射奥美拉唑40mg,q12h;②静脉注射奥美拉唑40mg,q12h,联合睡前一次静脉注射法莫替丁20mg;③静脉注射泮妥拉唑40mg,q12h;④静脉注射泮妥拉唑40mg,q12h,联合睡前一次静脉注射法莫替丁20mg。疗程均为5d。记录患者的止血时间、输血量、住院时间、转诊手术率、死亡率及住院总费用。结果4组患者的止血时间分别为1.3±1.0d、1.2±0.8d、1.3±0.8d、1.4±0.8d(P>0.05);输血量分别为1.7±2.8U、1.5±2.5U、1.6±2.4U、1.6±2.5U(P>0.05);再出血率为5.3%(1/19)、0、0、0(P>0.05);手术率和死亡率均为0;住院时间分别为10.6±7.4d、11.7±6.9d、12.9±5.9d、11.6±7.5d(P>0.05);住院总费用分别为7337.2±2133.1元、6908.6±2466.3元、7266.9±2993.1元、6646.3±2544.3元(P>0.05)。结论静脉注射奥美拉唑和泮妥拉唑均能有效治疗消化性溃疡出血,疗效及住院费用相当,夜间无需加用H2受体拮抗剂亦能达到同样疗效。
Objective To analyze the curative effect and curative effect of different proton pump inhibitors on peptic ulcer bleeding - cost analysis. Methods Eighty-three patients with peptic ulcer bleeding were randomly divided into 4 groups: ①inject omeprazole 40mg, q12h; ② intravenous omeprazole 40mg, q12h, combined with intravenous injection of famotidine 20mg ; ③ intravenous injection of prazolacrazole 40mg, q12h; ④ intravenous injection of prazolapo 40mg, q12h, combined with intravenous injection of famotidine 20mg before going to bed. Treatment are 5d. Record the patient’s bleeding time, blood transfusion, hospital stay, referral operation rate, mortality and hospitalization costs. Results The bleeding time of the four groups was 1.3 ± 1.0d, 1.2 ± 0.8d, 1.3 ± 0.8d and 1.4 ± 0.8d respectively (P> 0.05). The blood transfusion volumes were 1.7 ± 2.8U, 1.5 ± 2.5U and 1.6 ± 2.4U, 1.6 ± 2.5U (P> 0.05). The rate of rebleeding was 5.3% (1/19), 0,0,0 (P> 0.05) .The rates of operation and death were all 0. The hospital stay was 10.6 (P> 0.05). The total cost of hospitalization was 7337.2 ± 2133.1 yuan, 6908.6 ± 2466.3 yuan, 7266.9 ± 2993.1 yuan and 6646.3 ± 2544.3 yuan respectively > 0.05). Conclusion Intravenous omeprazole and prazolanole are effective in treating peptic ulcer bleeding. The curative effect and hospitalization cost are similar, and the same effect can be achieved at night without adding H2 receptor antagonist.