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目的分析原发于涎腺的非霍奇金淋巴瘤(NHL)的诊断、临床、病理、治疗及预后。方法16例原发于涎腺的NHL均为手术后病例。T细胞NHL 1例(中度恶性),B细胞NHL 15例,其中包括高度恶性1例,中度恶性4例,低度恶性10例[含粘膜相关淋巴组织(MALT)型NHL 6例]。按Ann Anbor分期法,IE11例,ⅡE5例。治疗均以放射治疗为主。放射治疗前后有9例行2~6周期化疗。结果本组5年生存率为67.5%,共有5例死亡,均为中高度恶性,均死于远处受累。结论本组提示涎腺NHL以低度恶性者居多,且有一定比例MALT型。低剂量放射治疗可作为此类患者的首选治疗。中高度恶性NHL则应行综合治疗。
Objective To analyze the diagnosis, clinical, pathology, treatment and prognosis of non-Hodgkin’s lymphoma (NHL) originating from the salivary gland. Methods 16 cases of primary NHL in the salivary gland were all postoperative cases. T cell NHL in 1 case (moderately malignant), B cell NHL in 15 cases, including 1 case of highly malignant, 4 cases of moderately malignant and 10 cases of low grade malignant [6 cases of mucosa associated lymphoid tissue (MALT) type NHL]. By Ann Anbor staging method, IE11 cases, Ⅱ E5 cases. Radiation therapy are the main treatment. Before and after radiotherapy, 9 cases received 2 ~ 6 cycles of chemotherapy. Results The 5-year survival rate of this group was 67.5%. A total of 5 deaths were reported, both of which were moderately and highly malignant and died of distant involvement. Conclusion This group suggests that salivary NHL is mostly low-grade and has a certain proportion of MALT type. Low-dose radiation therapy can be the preferred treatment for such patients. Highly malignant NHL should be combined with comprehensive treatment.