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目的观察地屈孕酮治疗孕妇黄体功能不全所致先兆流产的效果。方法选择该院收治的黄体功能不全所致先兆流产患者85例。采用密封信封法随机将85例患者分为地屈孕酮组42例和黄体酮组43例。地屈孕酮组给予地屈孕酮治疗,黄体酮组给予黄体酮治疗。观察2组患者治疗前后孕酮、雌二醇、人绒毛膜促性腺激素水平,比较2组止血时间和腰酸、腰痛缓解时间、保胎成功率及不良反应发生率。结果治疗前2组孕酮、雌二醇、人绒毛膜促性腺激素水平比较差异无统计学意义(P>0.05),治疗后2组患者孕酮、雌二醇、人绒毛膜促性腺激素水平均高于治疗前(P<0.05),2组治疗后比较差异无统计学意义(P>0.05);2组止血时间和腰酸、腰痛缓解时间比较差异无统计学意义(P>0.05)。地屈孕酮组不良反应总发生率为14.29%低于黄体酮组的44.19%,差异有统计学意义(χ2=11.914,P<0.05)。保胎成功率地屈孕酮组为95.24%,黄体酮组为88.37%,2组比较差异无统计学意义(P>0.05)。结论地屈孕酮与黄体酮治疗孕妇黄体功能不全所致的先兆流产均有较高的保胎成功率,均可有效改善激素水平,缓解患者出血和腰酸腰痛等临床症状,但地屈孕酮具有更高的安全性,且用药方便,患者依从性和接受度高,值得临床推广应用。
Objective To observe the effect of dydrogesterone on threatened abortion caused by corpus luteum in pregnant women. Methods Select the hospital admitted luteal insufficiency due to threatened abortion in 85 patients. Eighty-five patients were randomly divided into gendanzone group (n = 42) and progesterone group (n = 43) using sealed envelope method. The dorsprone group received droperidone treatment, and the progesterone group received progesterone treatment. The levels of progesterone, estradiol and human chorionic gonadotropin before and after treatment were observed in two groups. The bleeding time, the time of backache, the time of back pain relief, the success rate of miscarriage and the incidence of adverse reactions were compared between the two groups. Results There was no significant difference in progesterone, estradiol and human chorionic gonadotropin levels between the two groups before treatment (P> 0.05). After treatment, the levels of progesterone, estradiol, human chorionic gonadotropin (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05). There was no significant difference between the two groups in the time of hemostasis and the time of relieving LBP and LBP (P> 0.05). The total incidence of adverse reactions in dydrogesterone group was 14.29%, lower than 44.19% in progesterone group, the difference was statistically significant (χ2 = 11.914, P <0.05). The success rate of miscarriage was 95.24% in flexorone group and 88.37% in progesterone group. There was no significant difference between the two groups (P> 0.05). Conclusion Both dydrogesterone and progesterone have a higher success rate of miscarriage in threatened abortion induced by corpus luteum in pregnant women, which can effectively improve the hormone level and relieve the clinical symptoms such as hemorrhage and lumbar back pain in patients. However, With higher security, and convenient medication, patient compliance and high acceptance, it is worth clinical application.