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目的:考察医院制剂白苓利水胶囊的最佳制剂工艺路线。方法:根据药材质地,从饮片干燥、药材粉碎、水提工艺、浓缩、制粒工艺等角度进行考察优选。结果:优选制剂工艺为:白术、肉桂等60℃低温干燥后粉碎为生粉,泽泻、茯苓、猪苓、水煎每次8倍量水,煎煮两次后浓缩至相对密度1.20--1.25(60℃)与生粉混合,选择60℃以下干燥,粉碎成细粉,制粒,干燥,装入胶囊。结论:采用优选制剂工艺路线所生产白苓利水胶囊成品率高,工艺稳定可行。
Objective: To investigate the best preparation route of hospital preparation Bailing Li Shui Capsule. Methods: According to the quality of medicinal materials, from the Pieces drying, medicine crushing, water extraction process, concentration, granulation process perspective to study and optimize. Results: The preparation process is as follows: Atractylodes, cinnamon and other dried at 60 ℃ low temperature drying crushed into raw powder, Alisma orientalis, Poria, Polyporus, decoction of 8 times the amount of water, boiling twice and then concentrated to a relative density of 1.20 - 1.25 (60 ℃) mixed with raw powder, choose below 60 ℃ drying, crushing into fine powder, granulation, drying, into the capsule. Conclusion: The preparation process using the preferred preparation of high-yield capsule Ling Ling water content, process stability and feasibility.