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目的研究男性不育与染色体异常的关系,为临床治疗提供理论根据。方法采外周血细胞染色体培养,G显带分析(必要时加做C带),对闽南地区803例男性不育患者进行染色体核型分析。结果检出异常核型182例(包括Y染色体多态性)占全部被检者22.67%。主要涉及到染色体数目、结构异常,性反转、增加、缺失、易位、倒位及多态性等。结论:男性不育患者进行染色体检查对不育夫妇的诊断和治疗提供指导性依据,对生殖医学、优生优育起到重要意义,染色体异常是导致男性不育的主要原因之一。
Objective To study the relationship between male infertility and chromosomal abnormalities and provide theoretical basis for clinical treatment. Methods Chromosome karyotype analysis of 803 cases of male infertility in Minnan area was performed by using peripheral blood cell chromosome culture and G-banding analysis (if necessary, adding C-banding). Results 182 cases of abnormal karyotype (including Y chromosome polymorphism) accounted for 22.67% of all subjects. Mainly related to the number of chromosomes, structural abnormalities, sexual inversion, increase, deletion, translocation, inversion and polymorphism. Conclusion: Male infertility patients with chromosomal examination provide guidance for the diagnosis and treatment of infertile couples, reproductive medicine, prenatal and postnatal care is important, chromosomal abnormalities is one of the main causes of male infertility.