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目的 :观察硫胺素治疗慢性乙型肝炎的临床疗效。方法 :64例慢性乙型肝炎患者 ,随机分成甘草酸二铵组32例 ,硫胺素组32例。在治疗第8周、第48周结束时分别检测肝功能、HBVDNA定性和HBeAg阴转情况。结果 :甘草酸二铵组和硫胺素组肝功复常率在第8周两组间差异有显著性 (P<0 05) ;血清HBVDNA、HBeAg 转阴率两组间差异无显著性 (P>0 05) ;硫胺素组与甘草酸二铵组比较肝功能复常率明显降低 ,差异有显著性 (P<0 01)。连续用药48周后 ,硫胺素组肝功能复常率、血清HBVDNA、HBeAg 阴转率与治疗第8周结束时比较差异有显著性 (P<0 05) ,肝功复常率两组间差异无显著性 (P>0 05) ,血清HBVDNA、HBeAg阴转率硫胺素组与甘草酸二铵组比较差异有显著性 (P<0 05)。结论 :硫胺素可作为慢性乙型肝炎的基本治疗药物 ,长期服用硫胺素可降低病毒含量 ,稳定肝脏内环境 ,促进肝功能恢复
Objective: To observe the clinical effect of thiamine on chronic hepatitis B. Methods: Sixty-four patients with chronic hepatitis B were randomly divided into 32 cases of diammonium glycyrrhizinate group and 32 cases of thiamine group. At the end of the eighth week and the fourth week of treatment, liver function, HBVDNA qualitative and HBeAg negative were detected. Results: The rates of liver function recovery in the group of ammonium glycyrrhizinate and thiamine group were significantly different between the two groups at the 8th week (P <0.05). There was no significant difference between the two groups in serum HBVDNA and HBeAg P> 0.05). The rate of abnormal liver function in the thiamine group and the diammonium glycyrrhizinate group was significantly lower (P <0.01). After 48 weeks of continuous treatment, the rate of liver function regain, serum HBVDNA and HBeAg negative rate in the thiamine group were significantly different from those at the end of the 8th week (P <0.05) There was no significant difference (P> 0.05). Serum HBVDNA, HBeAg negative conversion rate of thiamine group and diammonium glycyrrhizinate group were significantly different (P <0 05). Conclusion: Thiamine can be used as the basic treatment of chronic hepatitis B, long-term use of thiamine can reduce the virus content, stabilize the liver environment, and promote liver function recovery