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目的 评价肺炎、腹泻患儿维生素A(VA)状况.方法 以相对剂量反应(RDR)和血清VA测定法研究60例肺炎,85例腹泻患儿的VA状况,并对这两种方法进行比较.RDR≥20%为亚临床VA缺乏(PVAD)状态的诊断标准.结果 43.3%的肺炎患儿和61.2%的腹泻患儿体内处于PVAD.肺炎和腹泻患儿的RDR值和血清VA值均呈负相关(r=-0.618,r=-0.476).诊断肺炎和腹泻患儿 PVAD时两种方法的诊断符合率分别为75.0%和71.8%.当血清VA≤ 0.35μmol/L,>1.40μmol/L时两种方法的符合率最高,血清VA在0.70～1.01μmol/L时两种方法的符合率最低.当血清VA值在0.70～1.01μmol/L,血清VA 测定法的评价结果并非完全可靠,进行个体判断需谨慎,此时RDR较血清VA测定法更为敏感可靠.结论 RDR不仅能用于评价健康人群,也可用于评价肺炎和腹泻患者体内VA状况;PVAD是肺炎和腹泻患儿值得注意的营养问题.
Objective To evaluate the status of vitamin A (VA) in children with pneumonia and diarrhea.Methods The VA status of 60 children with pneumonia and 85 children with diarrhea were studied by relative dose response (RDR) and serum VA test, and compared with each other. RDR≥20% was the diagnostic criteria of subclinical VA deficiency (PVAD) status.Results 43.3% of children with pneumonia and 61.2% of children with diarrhea were in PVAD.The children with pneumonia and diarrhea had a negative RDR value and serum VA value (R = -0.618, r = -0.476) .The diagnostic coincidence rates of the two methods in children with pneumonia and diarrhea were 75.0% and 71.8%, respectively.When serum VA≤ 0.35μmol / L,> 1.40μmol / L The coincidence rate of the two methods was the highest, and the coincidence rate of the two methods was the lowest when the serum VA was 0.70 ~ 1.01μmol / L. When the serum VA was between 0.70 ~ 1.01μmol / L, the result of serum VA was not completely reliable, Individual judgments need to be cautious, when RDR is more sensitive and reliable than serum VA assay.Conclusion RDR can be used not only in the evaluation of healthy people, but also in the assessment of VA status in patients with pneumonia and diarrhea; PVAD is worth noting in children with pneumonia and diarrhea Nutritional issues.