线粒体具有一套完整的Ca2 + 转运系统 ,包括两条摄取途径和三条释放途径。生理条件下 ,它们在细胞胞质与线粒体钙稳态维持以及细胞能量代谢中起重要作用 ,线粒体从胞质摄取的Ca2 + 可激活某些Ca2 + 敏感的呼吸酶和代谢过程。病理条件下 ,线粒体Ca2 + 转运发生紊乱 ,通过线粒体通透性转换导致细胞坏死或凋亡 Mitochondria have a complete Ca2 + transport system, including two uptake and three release pathways. Under physiological conditions, they play an important role in calcium homeostasis and mitochondrial calcium homeostasis and cellular energy metabolism, and Ca2 + uptake by the mitochondria from the cytoplasm activates certain Ca2 + -sensitive respiratory enzymes and metabolic processes. Under pathological conditions, disruption of mitochondrial Ca2 + transport leads to cell necrosis or apoptosis through mitochondrial permeability transition