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Alzheimer’s disease(AD)is the most common age-related dementia without cures.Between 2000 and 2017,deaths resulting from AD increased 145％.Based on the latest statistical data,more than 50 million people in the world suffered this devastating disease,which is one of major burdens in modern public health system(Alzheimer’s Association,2020).Genetic mappings have uncovered numerous susceptibility genetic variants,the vast majority of which are located in noncoding regions of the genome.