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可逆的蛋白磷酸化调控多种生化反应。蛋白磷酸酶是结核分枝杆菌的关键分子,不仅调控许多微生物自身的代谢,而且还可能干扰宿主细胞的信号传导。在结核分枝杆菌逃避宿主细胞的杀灭、阻止吞噬体与溶酶体融合中蛋白磷酸酶也起着重要的作用。选择性抑制这些信号途径可能是抗结核药物研发的新思路。本文综述了结核分枝杆菌蛋白磷酸酶MptpA、MptpB、MstP、SapM及其底物、磷酸酶表达调控基因和网络、抑制剂研发进展,以期为新抗生素靶标提供信息。
Reversible protein phosphorylation regulates a variety of biochemical reactions. Protein phosphatase is a key molecule of M. tuberculosis that not only regulates the metabolism of many microbes but also may interfere with the signaling of host cells. In Mycobacterium tuberculosis to evade the killing of host cells to prevent phagosomes and lysosomal fusion protein phosphatase also plays an important role. Selective inhibition of these signaling pathways may be a new way of developing anti-TB drugs. This review summarizes the advances in the development of mycobacterium tuberculosis protein phosphatases MptpA, MptpB, MstP, SapM and their substrates, phosphatase expression regulatory genes and networks, and inhibitors, with a view to providing information on new antibiotic targets.