Objective:The aim of the study was to investigate the expression and significance of cyclin E in gastric carcinoma.Methods:We detected the expression of cyclin E in three different pathologic types gastric carcinoma samples by immuno-histochemical staining technique (SP method).Results:In 59 gastric carcinoma samples the positive rate of cyclin E expression in gastric carcinoma was 55.93% (33/59), and it was significantly higher than that of normal gastric mucosa (10.53%, 2/19).The positive rates of cyclin E expression in poor differentiation group and mucoid carcinoma group were 68.75% (11/16) and 66.67% (16/24), respectively, and these were significantly higher than that in well-middle differentiation group (31.58%, 6/19), but there was no significant difference between the fronted two groups (P>0.05).Conclusion:The high expression of cyclin E is associated with the progression of gastric carcinoma and probably related to the behavior of cellular biology. Objective: The aim of the study was to investigate the expression and significance of cyclin E in gastric carcinoma. Methods: We detected the expression of cyclin E in three different pathologic types gastric carcinoma samples by immuno-histochemical staining technique (SP method). Results : In 59 gastric carcinoma samples the positive rate of cyclin E expression in gastric carcinoma was 55.93% (33/59), and it was significantly higher than that of normal gastric mucosa (10.53%, 2/19). The positive rates of cyclin E expression in poor differentiation group and mucoid carcinoma group were 68.75% (11/16) and 66.67% (16/24), respectively, and these were significantly higher than that in well-middle differentiation group (31.58%, 6/19) , but there was no significant difference between the fronted two groups (P> 0.05) .Conclusion: The high expression of cyclin E is associated with the progression of gastric carcinoma and probably related to the behavior of cellular biology.