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铁缺乏(iron deficiency,ID)是最常见的营养素缺乏症和全球性健康问题,6～24月婴幼儿是儿童铁缺乏的高危人群。啮齿类动物铁缺乏的研究也模仿人类,研究胎儿期到断奶期的幼鼠,此时是啮齿类动物神经系统发育的敏感期。在啮齿类动物研究中发现单纯铁缺乏不但可以导致脑内铁、单胺类化合物及其转运体、受体受到不同程度的影响,还影响中枢神经系统髓鞘化形成,导致幼鼠即使经过治疗后仍然表现为行为、学习、记忆等受损。本文就啮齿类动物铁缺乏对中枢神经系统的影响进行综述。
Iron deficiency (ID) is the most common nutrient deficiency and global health problem. From June to April, infants and young children are at high risk of iron deficiency in children. Studies of rodent iron deficiency also mimic humans and study fetal and fetal pups at this time as rodents are sensitive to the development of the nervous system. Rodents in the study found that iron deficiency alone can not only lead to intracerebral iron, monoamine compounds and their transporters, receptors are affected to varying degrees, but also affect the formation of the central nervous system myelination, resulting in pups even after treatment After the performance is still behavior, learning, memory damage. This article reviews the effects of rodent iron deficiency on the central nervous system.