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目的:比较腹腔镜手术与开腹手术治疗结直肠癌的临床效果。方法:选取武警海警总队医院2018年1月至2019年9月收治的结直肠癌患者94例，根据随机数字表法分为观察组47例与对照组47例。观察组行腹腔镜根治术，对照组行开腹根治术。比较两组围术期指标、术后康复指标、术后并发症及术前和术后24 h应激反应指标变化。结果:两组淋巴结清扫和手术时间差异无统计学意义(n P>0.05)；观察组术中出血量为(153.61±27.58)mL，少于对照组的(271.32±23.25)mL(n t＝22.371，n P<0.05)；观察组术后排气时间[(43.27±6.18)h]、肠鸣音恢复时间[(20.31±3.28)h]，均快于对照组[(67.38±9.91)h、(34.54±5.17)h](n t＝14.153、15.934，均n P<0.05)；观察组术后并发症发生率(4.26%)低于对照组(21.28%)(χn 2＝6.114，n P<0.05)；观察组术后24 h血清去甲肾上腺素[(92.13±10.45)μg/L]、C反应蛋白[(17.38±3.01)mg/L]、皮质醇[(137.87±23.15)μg/L]，均低于对照组[(136.27±15.42)μg/L、(26.73±2.34)mg/L、(185.42±27.39)μg/L](n t＝16.245、16.813、9.090，均n P0.05). The amount of bleeding of the observation group [(153.61±27.58)mL] was less than that of the control group [(271.32±23.25)mL] (n t=22.371, n P<0.05). In the observation group, the exhaust time [(43.27±6.18)h] and the recovery time of bowel sounds [(20.31±3.28)h] were faster than those in the control group [(67.38±9.91)h and (34.54±5.17)h] (n t=14.153, 15.934, all n P<0.05). The incidence of postoperative complications in the observation group (4.26%) was lower than that in the control group (21.28%) (χn 2=6.114, n P<0.05). The serum levels of norepinephrine (NE) [(92.13±10.45)μg/L], C-reactive protein (CRP) [(17.38±3.01)mg/L] and Cor [(137.87±23.15)μg/L] in the observation group were lower than those in the control group [(136.27±15.42)μg/L, (26.73±2.34)mg/L and (185.42±27.39)μg/L] (n t=16.245, 16.813, 9.090, all n P<0.05).n Conclusion:Laparoscopic radical resection of colorectal cancer has good effect on patients with colorectal cancer.It can speed up postoperative rehabilitation and reduce stress response.It is worthy of popularizing.