论文部分内容阅读
幽门螺杆菌（ＨＰ）是造成慢性胃炎，溃疡病的重要病原。我们用化学发光分析法测定胃窦部粘膜ＲＯＭ，观察ＨＰ（＋）和ＨＰ（一）胃粘膜ＲＯＭ产生的不同，８４例ＨＰ（干）发光值为３６．６４（９５％ＣＩ８．１８～２４８．２２）／ｍｇ／ｍｉｎ，５４例ＨＰ（一）为２．８８（９５％ＣＩ一２．０９～１２．６５）／ｍｇ／ｍｉｎ，ＨＰ（＋）组明显高于ＨＰ（一）组（Ｐ＜０．０１）。从两组发光值进行分析，其值同炎症有一定关系，炎症重发光值高；但炎症程度相似时，ＨＰ（＋）患者组其发光值比ＨＰ（－）组有明显增高，此与ＨＰ能激活巨噬细胞有关，抗氧化剂Ｎ－乙酰半胱氨酸（ＮＡＣ）可使ＲＯＭ降低，抑制ＨＰ造成的胃粘膜炎症。
Helicobacter pylori (HP) is caused by chronic gastritis, an important pathogen of ulcer disease. We measured the antral mucosal ROM using chemiluminescence analysis and observed differences in the HP (+) and HP (1) gastric mucosal ROMs. The 84 HP (dry) luminescence values were 36.64 (95% CI 8.18-248 .22) / mg / min, 54 cases of HP (a) was 2.88 (95% CI 2.09 ~ 12.65) / mg / min, HP (+) group was significantly higher than HP P <0.01). From the two groups of luminescence values analysis, the value of inflammation has a certain relationship, the inflammation re-luminescence value is high; but when the degree of inflammation is similar, HP (+) patients group luminescence value was significantly higher than HP (-) group, this HP Can activate macrophages, antioxidant N-acetylcysteine (NAC) can make ROM lower, inhibit HP caused gastric mucosal inflammation.