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目的：调查苏州市孕妇季节性流感的发病情况，评估孕妇流感的疾病负担。方法本项目依托于“中美新发和再发传染病合作项目”，由2015年10月开始队列建设，随后对纳入研究队列的孕妇进行随访调查，并对产生呼吸道感染症状的孕妇采集咽拭子进行实验室检测。结果截止2016年7月24日，本研究共纳入4438名孕妇进入队随访队列，其中早孕1539人，中孕2174人，晚孕726人，失访率为5．5％。呼吸道感染病例实际采样995例，采样率为80．83％。共有流感病毒核酸阳性样本68份，阳性率为6．8％，发病密度为0．08／（100人·周），阳性数最多的月份是2016年1月。结论本研究采用前瞻性队列研究方法对孕妇人群的流感发生情况进行调查，并进行了实验室病毒核酸检测，可提供妊娠期孕妇流感发生率的可信数据，在一定程度上弥补了此类研究的空白。“,”Objective To investigate the incidence rate and assess the disease burden of respiratory illness associated with influenza among pregnant women in Suzhou , China. Methods As a subproject of“The Sino-US Emerging and Re-emerging Infectious Diseases Program”,pregnant women were recruited in-to the cohort since October , 2015 and follow-ups were carried out .Throat swab for influenza was taken for laboratory test when the pregnant women got influenza-like symptoms . Results In total 4438 pregnant women recruit up to 24th July 2016, among which1 539 are early-pregnancy, middle-pregnancy accounted 2 174 and late-pregnancy took 726.Lost to follow-up rate was 5.5%.And 995 cases of throat swabs was taken and tested (80.83%), of which 68 cases were positive (6.8%).The incidence density was 0.08 per hundred person-weeks . Conclusion This prospective cohort study took laboratory test of influenza virus to investigate the incidence rate of respiratory illness associated with influenza among pregnant women can provide credible data about the incidence of influenza .To a certain extent , this study makes up the blank of such research .