目的:探讨阿米洛利对脑梗死急性期患者血清ox-LDL、炎症因子及MMP-9水平影响及其意义。方法:选取我院诊治的急性脑梗死患者120例,随机分为对照组和实验组,每组60例。两组患者均给予常规对症治疗,实验组在对照组的治疗基础上加用盐酸阿米洛利片。采用酶联免疫吸附法(ELISA)及免疫透射比浊法分别测定两组患者血清ox-LDL、炎症因子及MMP-9水平,并对患者神经功能缺损程度进行评分。结果:治疗后,两组患者神经功能均较治疗前明显改善,且实验组明显优于对照组,差异均具有统计学意义(P<0.05);治疗后,两组患者血清ox-LDL及MMP-9水平均低于治疗前,且实验组低于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者血清炎症因子TNF-α、IL-6及hs-CRP水平均低于治疗前,且实验组低于对照组,差异具有统计学意义(P<0.05)。结论:阿米洛利能够降低脑梗死急性期患者ox-LDL、TNF-α、IL-6、hs-CRP及MMP-9水平,减轻炎症反应,改善患者的神经功能。 Objective: To investigate the effect and significance of amiloride on serum ox-LDL, inflammatory cytokines and MMP-9 in patients with acute cerebral infarction. Methods: A total of 120 acute cerebral infarction patients diagnosed and treated in our hospital were randomly divided into control group and experimental group, 60 cases in each group. Both groups were given conventional symptomatic treatment, experimental group in the control group based on the treatment with amiloride hydrochloride tablets. Serum levels of ox-LDL, inflammatory cytokines and MMP-9 were measured by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry respectively. The severity of neurological deficits was evaluated. Results: After treatment, the neurological function of both groups was significantly improved compared with that before treatment, and the experimental group was significantly better than the control group, the difference was statistically significant (P <0.05); after treatment, serum ox-LDL and MMP -9 levels were lower than before treatment, and the experimental group was lower than the control group, the difference was statistically significant (P <0.05); after treatment, serum inflammatory cytokines TNF-α, IL-6 and hs-CRP levels were Lower than before treatment, and the experimental group was lower than the control group, the difference was statistically significant (P <0.05). Conclusions: Amiloride can reduce the levels of ox-LDL, TNF-α, IL-6, hs-CRP and MMP-9 in acute cerebral infarction patients, reduce the inflammatory reaction and improve the neurological function.