以炭末胶液在小鼠小肠内推进距离占小肠全长的百分数为指标,观察了侧脑室注射胰岛素对胃肠推进运动的影响。结果:(1)侧脑室注射胰岛素溶液后,能使胃肠推进运动增强,并具有剂量反应关系;(2)侧脑室内注射胰岛素所引起的上述效应,可被皮下注射阿托品所阻断。本工作表明,存在于脑内的胰岛素可能参与对胃肠运动机能的调节,并似是通过胆碱能神经实现的。 The effect of injecting insulin into the lateral ventricle on the gastrointestinal motility was observed with the percentage of carbon powder in the small intestine of mice as a percentage of the total length of the small intestine. Results: (1) After intracerebroventricular injection of insulin solution, gastrointestinal propulsion can be enhanced and dose-response relationship; (2) Intraventricular injection of insulin caused by the above effects can be subcutaneous injection of atropine block. This work shows that insulin present in the brain may be involved in the regulation of gastrointestinal motility and appears to be via the cholinergic nerve.