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目的：观察健康男性志愿者口服浙江海正药业股份有限公司生产的阿卡波糖片后血葡萄糖（GLU)变化及急性毒副作用。方法对40名健康男性志愿者单独服用蔗糖及蔗糖、阿卡波糖同时服用后，0、0.25、0.5、0.75、1、1.5、2、2.5、3、3.5、4h的血糖连续监测，并检测服用阿卡波糖前后血生化指标：葡萄糖(GLU)、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、尿素(Urea)、肌酐(Cr)；血液分析指标：红细胞（RBC）、白细胞(WBC)、血小板（PLT)、血红蛋白（Hb）的改变。结果蔗糖单独服用，血糖平均最低浓度（Cmin ）为4.26±0.67 mmol/L，血糖平均最高浓度（Cmax）为8.04±1.06 mmol/L，4h血糖时间曲线下面积（AUC (0-4)）为21.73±2.48 mmol/L/h。蔗糖、阿卡波糖同时服用，血糖Cmin为4.7±0.32 mmol/L，血糖Cmax为5.88±0.77 mmol/L，AUC (0-4)为20.14±1.53 mmol/L/h，血糖浓度明显降低，在0.25、0.5、0.75、1、2.5、3、3.5h有极显著性差异（p<0.01）,在4h有显著性差异（p<0.05）。蔗糖单独服用，血糖漂移（GE）为4.44±1.28 mmol/L，血糖坪浓度（Css）为5.43±0.62mmol/L。蔗糖、阿卡波糖同时服用GE为1.55±0.78 mmol/L，Css为5.14±0.38mmol/L，两者均降低，有极显著性差异（p<0.01）。除67.5%的受试者出现不同程度的腹泻或腹胀外，无明显不良反应。结论阿卡波糖有明显的降糖作用，能够有效地控制餐后血糖，并且改善餐后血糖波动，平稳血糖，值得临床推广运用。“,”Objective To investigate glucose-decreasing effect and acute side effects of therapy of acarbose made in Haizheng pharmaceutical company of Zhejiang province on healthy male volunteers. Methods After taken sucrose with acarbose and taken sucrose singly, blood glucose were continuous monitored by 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 3.5 and 4 hours, while biochemical indicators GLU, ALT, AST,Urea, Cr and blood component indexes RBC, WBC, PLT, and Hb were also detected. Results Blood glucose Cmin, Cmax and AUC (0-4) were 4.26±0.67 mmol/L, 8.04±1.06 mmol/L and 21.73±2.48 mmol/L/h respectively when sucrose was singly taken, while Blood glucose Cmin, Cmax and AUC (0-4) were 4.7±0.32 mmol/L, 5.88±0.77 mmol/L, 20.14±1.53 mmol/L/h respectively when sucrose was taken with arcarbose. Blood glucose was reduced obviously and there were very significant differences on 0.25, 0.5, 0.75, 1, 2.5, 3, 3.5 hours (P< 0.01). There was significant difference on 4 hours (P< 0.05). GE was 4.44±1.28 mmol/L and Css was 5.43±0.62mmol/L when sucrose was taken singly, while GE was 1.55±0.78 mmol/L and Css was 5.14±0.38mmol/L when sucrose was taken with arcarbose. They were both reduced and had very significant differences ( P< 0.01). Except for 67.5% participants exhibited bel yache or diarrhoea at different degrees, there was no obvious side effects. Conclusions Arcarbose has obvious glucose-decreasing effect and control post-prandial glycemia effectively. It ameliorates blood glucose excursion, stabilizes blood glucose, and deserves clinical applications.