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目的观察分析宫颈环切术治疗宫颈上皮瘤变(CIN)的近期及远期疗效。方法选取妇产科收治的宫颈上皮瘤变患者60例为研究对象,随机分为宫颈环切术(LEEP)组与宫颈冷刀锥切术(CKC)组,每组30例,于术后随访3个月和12个月观察比较2组复发和HPV感染的发生情况。结果近期疗效方面,LEEP组患者术中出血量、手术时间、住院时间、手术费用等手术相关指标均明显低于CKC组(P<0.01)。远期疗效方面,2组患者HPV感染发生率、CINⅠ级及Ⅱ级患者复发情况比较差异均无统计学意义(P>0.05);随访12个月CINⅢ级患者复发率LEEP组高于CKC组(P<0.05)。结论宫颈环切术治疗宫颈上皮瘤变患者,可有效减少术中出血量、缩短手术时间与住院时间、降低手术费用,近期疗效更优;但对于CINⅢ级患者,可选择传统宫颈冷刀锥切术进行治疗,以降低复发风险。
Objective To observe the short-term and long-term effects of cervical circumcision in the treatment of cervical epithelial neoplasia (CIN). Methods A total of 60 patients with cervical epithelial neoplasia who were admitted to obstetrics and gynecology were enrolled in this study. They were randomly divided into cervical ring excision (LEEP) group and cervical cold knife conization (CKC) group, 30 cases in each group. Three months and 12 months were observed and compared two groups of recurrence and HPV infection. Results In the short term, the intraoperative bleeding, operation time, hospitalization time and operation cost in LEEP group were significantly lower than those in CKC group (P <0.01). In terms of long-term curative effect, there was no significant difference in the incidence of HPV infection between the two groups (P> 0.05), and the relapse rate of CINⅠ and Ⅱ patients was significantly higher than that of the CKC group (P> 0.05) P <0.05). Conclusion Cervical circumcision for the treatment of patients with cervical epithelial neoplasia can effectively reduce intraoperative bleeding, shorten the operation time and hospitalization time, reduce the cost of surgery, the recent curative effect is better; but for CIN Ⅲ patients, you can choose the traditional cervical cold knife conization Surgery to reduce the risk of relapse.