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目的:探讨宫颈癌组织中的多形核嗜中性粒细胞(polymorphnuclear neutrophil,PMN)数量在预测宫颈癌复发中的作用。方法:回顾性分析1999年2月至2006年12月湖北省妇幼保健院及武汉大学中南医院92例初治宫颈癌Ⅰb~Ⅱa期患者的临床病理资料。采用免疫组织化学法检测宫颈癌组织中CD66b阳性的PMN数量,计算PMN数量平均值。将患者按宫颈癌组织中PMN浸润数量分组,数量>PMN平均值为A组,数量≤PMN平均值为B组。以无复发生存(recurrence free survival,RFS)为结点,采用Kaplan-Meier法进行单因素分析,采用Cox风险回归模型进行多因素分析。结果:A组的RFS期明显短于B组(P=0.001)。单因素及Cox风险回归模型多因素分析结果显示,腺癌(HR为3.020,95%CI为1.340~6.805,P=0.008)、淋巴结转移(HR为2.450,95%CI为1.065~5.637,P=0.035)、PMN浸润数量增加(HR为2.866,95%CI为1.274~46.447,P=0.011)为宫颈癌患者RFS的独立危险因素。结论:宫颈癌组织中PMN数量的增加与宫颈癌患者RFS期缩短相关,是宫颈癌患者预后不良的一个潜在预测指标。
Objective: To investigate the role of polymorphonuclear neutrophil (PMN) in predicting cervical cancer recurrence in cervical cancer. Methods: The clinical and pathological data of 92 patients with newly diagnosed cervical cancer Ⅰb ~ Ⅱa in Hubei MCH and Wuhan Zhongnan Hospital from February 1999 to December 2006 were retrospectively analyzed. The number of CD66b-positive PMN in cervical cancer tissues was detected by immunohistochemistry, and the average number of PMNs was calculated. According to the number of patients with cervical cancer, the number of PMN infiltration, the number of> PMN average for the A group, the average number ≤ PMN group B. Unrecurrence free survival (recurrence free survival, RFS) as the node, using Kaplan-Meier method for univariate analysis, using Cox risk regression model for multivariate analysis. Results: The RFS duration in group A was significantly shorter than that in group B (P = 0.001). Multivariate analysis showed that adenocarcinoma (HR 3.020, 95% CI 1.340-6.805, P = 0.008), lymph node metastasis (HR 2.450, 95% CI 1.065-5.637, P = 0.035). The number of infiltrating PMNs (HR 2.866, 95% CI 1.274-46.447, P = 0.011) was an independent risk factor for RFS in patients with cervical cancer. Conclusion: The increase of PMN in cervical cancer is related to the shortening of RFS in patients with cervical cancer, which is a potential predictor of poor prognosis in patients with cervical cancer.