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目的探讨了血清糖类抗原-199(CA199)、胱抑素C(CysC)和同型半胱氨酸(Hcy)在胰腺癌中的应用价值。方法应用放射性免疫分析法,胶乳增强免疫比浊法和免疫化学法对39例胰腺癌患者进行了血清CA199、CysC和Hcy水平检测,并与49名正常人做比较。结果胰腺癌患者血清CA199、CysC和Hcy水平均非常显著地高于正常人组(P<0.01)。CA199的敏感度和特异度分别为84.6%,79.6%;CysC的敏感度和特异度分别为69.2%,61.2%;Hcy的敏感度和特异度分别为71.8%,67.3%。联检CA199,CysC和Hcy的敏感度和特异度为97.4%,98.0%。结论采用CA199,CysC和Hcy联检,对胰腺癌的早期诊断具有一定的临床价值。
Objective To investigate the value of serum carbohydrate antigen -199 (CA199), cystatin C (CysC) and homocysteine (Hcy) in pancreatic cancer. Methods Serum levels of CA199, CysC and Hcy were measured in 39 patients with pancreatic cancer by radioimmunoassay, latex enhanced immunoturbidimetry and immunochemical methods and compared with 49 healthy controls. Results The levels of CA199, CysC and Hcy in patients with pancreatic cancer were significantly higher than those in normal controls (P <0.01). The sensitivity and specificity of CA199 were 84.6% and 79.6%, respectively. The sensitivity and specificity of CysC were 69.2% and 61.2%, respectively. The sensitivity and specificity of Hcy were 71.8% and 67.3%, respectively. The sensitivity and specificity of joint CA199, CysC and Hcy were 97.4% and 98.0% respectively. Conclusion The combination of CA199, CysC and Hcy can be used to diagnose pancreatic cancer early.