A simple synthetic approach for the transformation of(S)-Ugi's amine

来源 :Chinese Chemical Letters | 被引量 : 0次 | 上传用户:GYF463878110
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A simple synthetic approach for the transformation of(S)-Ugi’s amine,another configuration of(R)-Ugi’s amine,one of the most widely used intermediate in the preparation of chiral ferrocene-based ligands,has been developed via esterification using anhydride,alkaline hydrolysis and active manganese dioxide oxidation,and the corresponding ferrocenyl ketone was afforded in good yields. A simple synthetic approach for the transformation of (S) -Ugi’s amine, another configuration of (R) -Ugi’s amine, one of the most widely used intermediate in the preparation of chiral ferrocene-based ligands, has been developed via esterification using anhydride, alkaline hydrolysis and active manganese dioxide oxidation, and the corresponding ferrocenyl ketone was afforded in good yields.
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