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本文回顾近年来在摄食中枢的神经化学机制方面的研究进展,较重要的有:(1)用所谓下丘脑“饱中枢”VMH粗提物的抗体和下丘脑糖感受器受体结合,进一步证明糖感受器的存在;(2)脑室或脑组织灌流的实验提示,脑脊液中存在着“饱因子”和“饿因子”;(3)对于脑内去甲肾上腺素通路在摄食控制中的作用有了较详尽的研究;(4)摄食中枢不限于下丘脑,边缘系统、纹状体和大脑皮层都参与摄食的控制;所涉及的神经化学物质也不限于去甲肾上腺素,其它单胺、氨基酸和多种神经肽也都参与。
In this review, we review the recent advances in the neurochemical mechanisms of the feeding center. More important are: (1) the use of the so-called “full-center” VMH crude extract of the hypothalamus in combination with hypothalamic glycol receptor receptors, further demonstrating that sugars (2) experiments of perfusion in ventricles or brain tissue suggest that “full factor” and “starvation factor” exist in cerebrospinal fluid; and (3) there is a greater effect on the control of ingestion of norepinephrine pathway in the brain Exhaustive studies; (4) feeding centers not limited to the hypothalamus, limbic system, striatum and cerebral cortex are involved in the control of feeding; the neurochemicals involved are not limited to norepinephrine, other monoamines, amino acids and more Neuropeptides are also involved.