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作者通过对4例罕见的皮肤麦克细胞癌进行临床病理观察研究,结合文献复习,认为此癌多见于中老年妇女,全身各部位均可发生,以头颈部多见,区域淋巴结转移率高。免疫组化染色显示,肿瘤细胞角蛋白、上皮膜抗原和S100阳性。电镜观察发现肿瘤细胞胞浆基质中有多少不等的神经内分泌颗粒,分布弥散无规律。观察结果表明此癌来源于上皮组织,并且具有向神经内分泌方向分化的特点。
The authors conducted a clinicopathologic observation of 4 cases of rare skin Mack cell carcinoma. Combined with review of the literature, this author believes that this cancer is more common in middle-aged and elderly women. It can occur in various parts of the body, and is common in the head and neck. The rate of regional lymph node metastasis is high. Immunohistochemical staining showed that tumor cell keratin, epithelial membrane antigen and S100 were positive. Electron microscopy revealed that there were many different neuroendocrine particles in the cytoplasm of the tumor cells, and the distribution was irregular. The observations show that this cancer is derived from epithelial tissue and has a characteristic of differentiating into a neuroendocrine direction.