洋地黄制剂使用至今已逾200年,随着心脏病在世界各地发病率逐年增加的趋势,洋地黄的应用也越来越广泛。如美国,地高辛已列为第八位常用药物。虽然洋地黄中毒发生率近年有所下降,但仍达10——30％。一旦发生洋地黄中毒,死亡率可达5——10％。 多年来洋地黄中毒的传统治疗方法仅限于对症治疗,直至1976年,Smith氏首次应 Digitalis preparations have been used for more than 200 years, with the incidence of heart disease in various parts of the world increasing trend, the application of digitalis more and more widely. Such as the United States, digoxin has been ranked as the eighth commonly used drugs. Although the incidence of digitalis poisoning has declined in recent years, but still up to 10 - 30%. In the event of digitalis poisoning, the mortality rate of up to 5-10%. The traditional treatment of digitalis poisoning over the years is limited to symptomatic treatment until 1976, Smith’s first time