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目的:观察芪葵方对糖尿病肾病患者血糖、血脂、肾功能以及尿足细胞相关蛋白的影响。方法:2014年1月~2015年12月在南京中医药大学附属医院/江苏省中医院内分泌科就诊的128例糖尿病肾病患者按随机数字表分为观察组和对照组,对照组患者均接受常规治疗,观察组患者在接受常规治疗的同时口服芪葵方(1剂/天,分2次服用),两组患者的疗程均为8周。治疗前及治疗8周时检测两组患者血糖指标、血脂指标、肾功能指标和尿足细胞相关蛋白PCX、Nephrin水平。结果:(1)观察组患者FBG、2h BG、Hb A1C水平均较对照组显著降低(P<0.01);(2)观察组患者TG、TC、LDL-C水平均较对照组显著降低(P<0.01),HDL-C水平显著高于对照组(P<0.01);(3)观察组患者Scr、Umalb、ACR均较对照组显著降低(P<0.01),GFR显著高于对照组(P<0.01);(4)观察组患者PCX/Ucr和Nephrin/Ucr较对照组显著降低(P<0.01);(5)观察组总有效率显著高于对照组(P<0.01)。结论:芪葵方对糖尿病肾病患者具有良好的治疗作用,可降低血糖,调节血脂紊乱,改善肾功能,并能显著降低患者尿足细胞相关蛋白PCX和Nephrin水平。
Objective: To observe the effect of Qikui Fang on blood glucose, blood lipid, renal function and urinary podocyte related protein in patients with diabetic nephropathy. Methods: From January 2014 to December 2015, 128 patients with diabetic nephropathy treated by Department of Endocrinology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine / Jiangsu Provincial Hospital of Traditional Chinese Medicine were divided into observation group and control group according to random number table. Patients in control group received routine Treatment, observation group patients receiving conventional therapy at the same time oral Qiyufang (1 / day, 2 doses), two groups of patients were treated for 8 weeks. Before treatment and 8 weeks after treatment, the blood glucose, blood lipid, renal function indexes and PCX and Nephrin levels of the two groups were detected. Results: (1) The levels of FBG, 2h BG and Hb A1C in the observation group were significantly lower than those in the control group (P <0.01); (2) The levels of TG, TC and LDL-C in the observation group were significantly lower than those in the control group (P <0.01); (3) The Scr, Umalb and ACR in the observation group were significantly lower than those in the control group (P <0.01), and the GFR was significantly higher than that in the control group (P <0.01). (4) PCX / Ucr and Nephrin / Ucr in the observation group were significantly lower than those in the control group (P <0.01). (5) The total effective rate in the observation group was significantly higher than that in the control group (P <0.01). Conclusion: Qiguoi Formula has a good therapeutic effect on patients with diabetic nephropathy, which can lower blood glucose, regulate dyslipidemia, improve renal function, and significantly reduce the levels of PCX and Nephrin in patients with diabetic nephropathy.