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目的研究对帕金森病进行美多巴、森福罗联合治疗的效果情况。方法将62例诊断为帕金森病的病患,分为三组,随机选取其中20例记为对照组,该组仅给药美多巴片。以药量逐渐梯度加大为原则。药量区间为:0.25～0.75g/d,平均0.5g/d。用药112d。美多巴联合森福罗组共21例病患,此组在给其美多巴片药量与对照组一样多外,另增加给药森福罗。开始剂量为0.375mg/d,每5～7d增加剂量,给药平均值为0.75mg/d。用药112d。美多巴联合吡贝地尔组共21例病患。此组在给其美多巴片药量与对照组一样多外,另增加给药吡贝地尔50～150mg/d,分1至3次用药。用药时间112d。疗程结束后分别比较三种用药方式对帕金森病患的疗效和影响。结论使用美多巴联合森福罗治疗帕金森病,对比单独使用美多巴或者美多巴联合吡贝地尔,在总有效率方面以及患者不良反应等疗效显著。值得临床推荐用药。
Objective To study the effect of combined treatment of metoprolol and salmeterol on Parkinson’s disease. Methods Sixty-two patients diagnosed as Parkinson’s disease were divided into three groups, of which 20 were randomly selected as the control group. The group was given only methomyl tablets. To gradually increase the dose gradient as the principle. Dosage interval: 0.25 ~ 0.75g / d, an average of 0.5g / d. Medication 112d. 21 cases of patients with metoprolol combined with the sunfoiluo group, this group to its methomyl tablets as much as the amount of the control group, the other plus the treatment of salbutamol. The initial dose of 0.375mg / d, every 5 ~ 7d increase the dose, the average administration of 0.75mg / d. Medication 112d. A total of 21 patients were treated with metoprolol and piribedil. This group to its methomyl tablets as much as the amount of the control group, another additional administration of piribedil 50 ~ 150mg / d, 1 to 3 times the drug. Medication time 112d. After the course of treatment were compared three kinds of medication for Parkinson’s disease efficacy and impact. Conclusions The treatment of Parkinson’s disease with combination of metoparaffin and salmeterol is more effective than the combination of metopar or metopaba combined with piribedil in total effective rate and patient adverse reactions. Worth clinical recommendation medication.