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唐恩氏综合征(Down syndrome)的住院病人和其他原因智能低下作对照管理的病人,用免疫粘附血凝法检测所存在的抗甲型肝类抗原的抗体,表现存有抗甲型肝炎抗原抗体的总计75.1％(175/233),无年令、性别的差别。对乙型肝炎表面抗原(HBsAg)或它的抗体(抗—HBs)有反应的病人比对这些指标阴性反应的病人对甲型肝炎抗体(抗—HA)起反应显著更为频繁,与乙型肝炎的血清学指标相反,抗—HA出现不是决定于智能低下的病因和在初次受感染的年令,发现抗—HA的阳性率与住院时间是密切相关的。本研究更肯定了认为许多严密的收容智能低下病人的病院甲型肝炎高流行地区而抗—HA的形成受免疫不足或免疫未成熟性的影响不大。
Inpatients with Down syndrome and other patients with poor intelligence under controlled management were tested for the presence of anti-hepatitis A anti-hepatitis B antibodies by immunoadsorbent hemagglutination Antigen antibodies total 75.1% (175/233), no year, gender differences. Patients who responded to hepatitis B surface antigen (HBsAg) or its antibodies (anti-HBs) reacted significantly more frequently to hepatitis A antibodies (anti-HA) than those who were negative for these indicators, In contrast to serological markers of hepatitis, anti-HA did not appear to be attributable to the cause of mental retardation and in the first year of infection, the positive rate of anti-HA was found to be closely related to length of stay. This study is even more positive that many closely hospitalized patients with intellectual low-risk areas of hepatitis A are endemic and the formation of anti-HA is less affected by immunodeficiency or immune immaturity.